A vitamin is a substance that makes you sick if you do not eat it. Several international scientific research has found a favorable relationship between anti-oxidant vitamins and heart diseaase. The most often used vitamins are vitamin C and E. Vitamin C is a water soluble vitamin. Vitamin C is also important for the healing of wounds, and for the maintenance and repair of cartilage, bones, and teeth. Foods that have a tendency to be the highest sources of vitamin C include green peppers, citrus fruits and juices, garden strawberry, tomato, broccoli, turnip greens along with other leafy greens, sweet and white potatoes, and cantaloupe.
E vitamin is fat soluble and has anti-oxidant properties. It’s found in vegetables and seed oils, in wheat germ and, in smaller quantities, in meats, fish, vegetables and fruits. Beta carotene has anti-oxidant, immuno modulatory, anti carcinogenic and anti atherogenic activity. It’s found in food carotenoids including fruits, yellow orange veggies and deep green vegetables. In the year 1985, Verlangieri and associated reported in Med Hypotheses that individuals who’d a higher consumption of vegetables and fruits had lower death rates from coronary disease. Riemersma and associates in 1991 reported in the Lancet that angina patients had lower plasma E vitamin levels when compared to controls.
An inverse relationship between plasma E vitamin levels and coronary disease artery was also established in a report published by Luoma and co-workers from Northern Finland, in 1995. The National Health and Nutrition Examination Survey-I cohort study found an inverse relationship between the highest vitamin C intake and coronary disease risk over 10 years in 11, 349 U.S. Women and men 25 to 74 years of age. The heart protective effects of vitamin C was again suggested in 1994, when Knekt’s group found an inverse relationship between vitamin C intake and coronary mortality in an epidemiology study, and reported these results in the American Journal of Epidemiology.
This leads to plaque formation and progression to rupture or coronary artery blockage and an eventual myocardial infarction. The Low-density lipoprotein oxidation can be reduced by anti-oxidants in plasma, the Low-density lipoprotein particle and the cell wall. Vitamins E and B carotene are the major fat soluble anti-oxidant vitamins. By lessening Low-density lipoprotein oxidation, atherosclerosis progression should be retarded, and perhaps regressed. Anti-oxidants also improve arterial wall reactivity and increase endothelial nitric oxide release. Based on these research studies, the medical community started recommending E vitamin in a dosage of 400 IU per day and vitamin C in a dosage of 500 to 1, 000 mg per day, as a beneficial supplement for coronary disease.
Nevertheless, subsequent larger and better organized studies fail to confirm benefits. A meta analysis of 68 randomized trials that included over 230, 000 participants was published in the Feb 28, 2007 issue of the Journal of the American Medical Association.